Publications
Highlights
Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays
Van den Bergh B., Ruelens P., Agten L., Van Moll L., Geerts N., Verstraete L., Nguyen S., De Vooght L., Verstraeten N., Cos P., Michiels, J.
Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery
Bollen C., Louwagie S., Deroover F., Duverger W., Khodaparast L., Khodaparast L., Hofkens D., Schymkowitz J., Rousseau F., Dewachter L., Michiels J.
Highlighted in Trends in Microbiology | Covered by 'News Medical' | Covered by 'Phys.org' | Covered by 'The Microbiologist'
The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli
Dewachter L., Deckers B., Mares-Mejía I., Louwagie E., Vercauteren S., Matthay P., Brückner S., Möller A.M., Narberhaus F., Vonesch S.C., Versées W.*, Michiels J.*
Antibiotic dose and nutrient availability differentially drive the evolution of antibiotic resistance and persistence
Windels E.M., Cool L., Persy E., Swinnen J., Matthay P., Van den Bergh B., Wenseleers T., Michiels J.
Deep mutational scanning of essential bacterial proteins can guide antibiotic development
Dewachter L., Brooks AN., Noon K., Cialek C., Clark-ElSayed A., Schalck T., Krishnamurthy N., Versées W., Vranken W., Michiels J.
Nature Communications Editors’ Highlight | Covered by 'Leuven actueel'
Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis
Van den Bergh B., Schramke H., Michiels JE., Kimkes TEP., Radzikowski JL., Schimpf J., Vedelaar SR., Burschel S., Dewachter L., Lončar N., Schmidt A., Meijer T., Fauvart M., Friedrich T., Michiels J.*, Heinemann M.*
Population bottlenecks strongly affect the evolutionary dynamics of antibiotic persistence
Windels EM., Fox R., Yerramsetty K., Krouse K., Wenseleers T., Swinnen J., Matthay P., Verstraete L., Wilmaerts D., Van den Bergh B.*, Michiels J.*
HokB monomerization and membrane repolarization control persister awakening
Wilmaerts D., Dewachter L., De Loose P-J., Bollen C., Verstraeten N.*, Michiels J.*
Interview with 'Journal of Life Sciences' | Interview with 'De Artsenkrant' | EOS blog post | Covered by 'Phys.org'
Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates
Windels EM.#, Michiels JE.#, Fauvart M., Wenseleers T., Van den Bergh B., Michiels J.
Readers' Choice: The best of The ISME Journal 2019 | Covered by 'Plus Magazine' | Covered by 'Engineeringnet'
Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence
Van den Bergh B.#, Michiels JE.#, Wenseleers T.#, Windels EM., Vanden Boer P., Kestemont D., De Meester L., Verstrepen KJ., Verstraeten N., Fauvart M., Michiels J.
Covered by 'Phys.org' | Covered by 'Medical Daily' | Covered by 'Science Alert' | Covered by 'Eos Wetenschap'
Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery
Bollen C., Louwagie S., Deroover F., Duverger W., Khodaparast L., Khodaparast L., Hofkens D., Schymkowitz J., Rousseau F., Dewachter L., Michiels J.
Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery
Bollen C., Louwagie S., Deroover F., Duverger W., Khodaparast L., Khodaparast L., Hofkens D., Schymkowitz J., Rousseau F., Dewachter L., Michiels J.
Highlighted in Trends in Microbiology | Covered by 'News Medical' | Covered by 'Phys.org' | Covered by 'The Microbiologist'