Publications

Deep mutational scanning of essential bacterial proteins can guide antibiotic development

Dewachter L., Brooks AN., Noon K., Cialek C., Clark-ElSayed A., Schalck T., Krishnamurthy N., Versées W., Vranken W., Michiels J.

Nature Communications 2023, 14(1):241

Nature Communications Editors’ Highlight

Covered by 'Time.News'

Covered by 'Flanders.bio'

Covered by 'Leuven actueel'

Transcription-coupled DNA repair underlies variation in persister awakening and the emergence of resistance

Wilmaerts D., Focant C., Matthay P., Michiels J.

Cell Reports 2022, 8(9):110427

Covered by 'De Morgen'

Covered by 'HLN'

Covered by 'De Gelderlander'

Covered by 'MediQuality'

Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

Van den Bergh B., Schramke H., Michiels JE., Kimkes TEP., Radzikowski JL., Schimpf J., Vedelaar SR., Burschel S., Dewachter L., Lončar N., Schmidt A., Meijer T., Fauvart M., Friedrich T., Michiels J.*, Heinemann M.*

Nature Communications 2022, 13(1):546

Covered by 'Science LinX'

Population bottlenecks strongly affect the evolutionary dynamics of antibiotic persistence

Windels EM., Fox R., Yerramsetty K., Krouse K., Wenseleers T., Swinnen J., Matthay P., Verstraete L., Wilmaerts D., Van den Bergh B.*, Michiels J.*

Molecular Biology and Evolution 2021, 38(8):3345-3357

HokB monomerization and membrane repolarization control persister awakening

Wilmaerts D., Dewachter L., De Loose P-J., Bollen C., Verstraeten N.*, Michiels J.*

Molecular Cell 2019, 75(5):1031-1042

Interview with 'Journal of Life Sciences'

Interview with 'De Artsenkrant'

EOS blog post

Covered by 'Phys.org'

Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates

Windels EM.#, Michiels JE.#, Fauvart M., Wenseleers T., Van den Bergh B., Michiels J.

The ISME Journal 2019, 13(5):1239-1251

Readers' Choice: The best of The ISME Journal 2019

Covered by 'Knack'

Covered by 'Engineeringnet'